Fibroid Uterus
Fibroids are non-cancerous growths that develop in the muscular wall of the uterus. Uterine fibroids or leiomyomas, involve a combination of genetic, hormonal, and cellular factors.
Treatment approaches include hormonal therapies, non-hormonal medications, minimally invasive procedures (such as uterine artery embolization or focused ultrasound), and, in severe cases, surgical interventions like myomectomy or hysterectomy. The choice of treatment depends on factors such as the size, location, and symptoms associated with the fibroids, as well as the patient's reproductive goals and overall health.
It is important to consult with your Gynaecologist for an accurate diagnosis and to discuss appropriate management options based on individual circumstances and preferences.
Here are some key aspects:
1. Genetic predisposition: Genetic factors play a role in the development of fibroids. Studies have identified certain genetic alterations and variations that are associated with an increased risk of developing fibroids.
2. Hormonal influence: Hormones, particularly estrogen and progesterone, have a significant impact on fibroid development and growth. Estrogen promotes the growth of fibroids, as they contain receptors for estrogen. Scientific evidence supports the role of estrogen in stimulating fibroid growth and progesterone in maintaining their size. Hormonal fluctuations during the menstrual cycle and pregnancy can influence fibroid growth patterns.
3. Cellular abnormalities: Fibroids arise from abnormal growth and proliferation of smooth muscle cells in the uterine wall. There are specific cellular changes in fibroids, including alterations in cell signaling pathways, increased production of growth factors, and changes in extracellular matrix composition. These cellular abnormalities contribute to the development and growth of fibroids.
4. Blood vessel abnormalities: Fibroids are known to have increased blood vessel density compared to the surrounding normal tissue. Abnormal development and remodeling of blood vessels within fibroids contribute to their growth and survival.
5. Other factors: Other factors such as obesity, metabolic disorders, and racial/ethnic disparities have also been associated with an increased risk of developing fibroids, although the exact mechanisms are not fully understood.