Till date, the following factors have been determined:

1. Genetic factors: Scientific research indicates that chromosomal abnormalities in the fetus are the most common cause of RPL. Studies have shown that genetic abnormalities, both in the fetus and the parents, can contribute to recurrent miscarriages. Genetic testing, such as karyotyping or chromosomal microarray analysis, can help identify these abnormalities and guide management decisions.

2. Hormonal and endocrine factors: Hormonal imbalances, including abnormalities in progesterone levels and thyroid function, have been associated with RPL. Scientific evidence supports the evaluation and management of hormonal and endocrine factors as part of RPL investigations.

3. Anatomical factors: Uterine abnormalities, such as septate uterus or cervical incompetence, have been identified as potential causes of RPL. Assessment of the uterine structure through imaging techniques, such as hysteroscopy or ultrasound, can help detect and address these anatomical factors.

4. Immunological factors: The role of immunological factors in RPL is an area of ongoing research. Some studies suggest that certain autoimmune conditions or immune system dysfunctions may contribute to recurrent miscarriages. However, the scientific evidence in this area is still evolving, and more research is needed to establish clear associations and effective interventions.

5. Thrombophilic factors: Thrombophilic disorders, which affect blood clotting, have been investigated as potential contributors to RPL. Scientific studies have explored the role of genetic and acquired thrombophilias, such as antiphospholipid syndrome, in recurrent miscarriages.